T. Murayama

Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53's role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

This study investigates whether MG53 interacts with the insulin receptor and affects Akt phosphorylation in muscle, heart, and liver tissues, finding low binding affinity and no effect on insulin signaling.

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.

Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery

The paper establishes a reconstituted DICR platform in HEK293 cells to validate skeletal muscle disease mutations and test drug candidates.

Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2

This paper quantitatively examines how CPVT-linked RyR2 mutations affect ER Ca2+ release threshold by measuring CICR activity and simulating cellular responses.

Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations

This study identifies two gating mechanisms of RyR2 and shows how mutations affect channel function.

Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia

The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.

Zinc-binding motif acts as an oxidative stress sensor to regulate TRPM7 channel activity

This study identifies the zinc-binding motif in TRPM7 as critical for oxidative stress sensing and Mg2+-dependent regulation of channel activity.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

Domain organization and conformational change of dynactin p150

This study uses electron microscopy to investigate the structure and conformational changes of the dynactin p150 subunit, revealing domain organization and a flexible sidearm with a coiled-coil domain.

Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility

This study identifies two antagonistic domains in dynactin that regulate dynein motility, with DCTN1A promoting processive movement and DCTN1B inhibiting it.