Author

J. Suzuki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Assay:electrophysiology· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Y. Kirichok· 3 shared K. Kanemaru· 2 shared M. Iino· 2 shared N. Chatterjee· 2 shared N. Kurebayashi· 2 shared T. Murayama· 2 shared T. Sakurai· 2 shared V. Olivas· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

Y. Kirichok

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Author profile →

6 papers

Recent·Most cited

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring

M. Takenaka, M. Kodama, T. Murayama, M. Ishigami-Yuasa, S. Mori, R. Ishida, J. Suzuki, K. Kanemaru, M. Sugihara, M. Iino, A. Miura, H. Nishio, S. Morimoto, H. Kagechika, T. Sakurai, N. Kurebayashi

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.

bioRxiv · Aug 21, 2023 · PreprintPharmacology & Toxicology

Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2

N. Kurebayashi, T. Murayama, R. Ohta, J. Suzuki, K. Kanemaru, S. Ohno, M. Horie, M. Iino, F. Yamashita, T. Sakurai

This paper quantitatively examines how CPVT-linked RyR2 mutations affect ER Ca2+ release threshold by measuring CICR activity and simulating cellular responses.

bioRxiv · Jan 16, 2021Physiology

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

S. Nanjo, W. Wu, N. Karachaliou, C. Blakely, J. Suzuki, S. Ali, L. Kerr, V. Olivas, J. Shue, J. Rotow, M. Mayekar, F. Haderk, N. Chatterjee, A. Urisman, Y. Kirichok, , T. Bivona

This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

Effects of hyperbaric environment on endurance and metabolism are exposure time-dependent in well-trained mice

J. Suzuki

This study shows that hyperbaric exposure improves exercise performance and metabolism in trained mice, with 60 minutes of exposure providing greater benefits for fatty acid metabolism.

bioRxiv · Aug 26, 2020Physiology

The Mechanism of MICU-Dependent Gating of theMitochondrial Ca2+ Uniporter

V. Garg, I. Paranjpe, T. Unsulangi, J. Suzuki, L. S. Milescu, Y. Kirichok

The paper uses patch-clamp analysis to show MICUs do not occlude the mitochondrial Ca2+ uniporter but enhance its activity with elevated cytosolic Ca2+.

bioRxiv · Apr 4, 2020Biophysics

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology