T. Sakurai

Three years of insecticide resistance evolution and associated mechanisms in Aedes aegypti populations of Ouagadougou, Burkina Faso.

This study tracks insecticide resistance in Aedes aegypti over three years in Burkina Faso, showing increasing resistance to pyrethroids linked to kdr mutations.

Synaptic plasticity in the medial preoptic area of male mice encodes social experiences with female and regulates behavior toward young

This study identifies synaptic plasticity in the medial preoptic area of male mice as critical for shifting from aggressive to paternal behavior after mating and interaction with pups.

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.

Linear contraction of stress fibers generates cell body rotation

The paper shows that linear contraction of stress fibers drives cell body rotation in migrating keratocytes through simple soft-body mechanics.

Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery

The paper establishes a reconstituted DICR platform in HEK293 cells to validate skeletal muscle disease mutations and test drug candidates.

Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease

This study identifies lipid flippase dysfunction as a key pathogenic event in Alzheimer's disease and presents a peptide therapy to restore endosomal function.

Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2

This paper quantitatively examines how CPVT-linked RyR2 mutations affect ER Ca2+ release threshold by measuring CICR activity and simulating cellular responses.

Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations

This study identifies two gating mechanisms of RyR2 and shows how mutations affect channel function.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

Domain organization and conformational change of dynactin p150

This study uses electron microscopy to investigate the structure and conformational changes of the dynactin p150 subunit, revealing domain organization and a flexible sidearm with a coiled-coil domain.