NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner
T. Bian, Y. Wang, J. F. Botello, Q. Hu, Y. Jiang, A. Zingone, P. A. Corral, F. Z. Aly, Y. Wu, B. M. Ryan, L. Jin, C. Xing
This study shows that (R)-NNAL promotes lung cancer progression by deactivating LKB1 through β-AR signaling, while (S)-NNAL has weaker effects.
bioRxiv · Jun 15, 2021 · PreprintCancer Biology