Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies
Niladri Bhusan Pati, Brian K. Chung, Kristian Holm, Frank Sætre, Henrik Mikael Reims, Anders Theodor Aasebo, Tobias Gedde‐Dahl, K.V. Sreelakshmi, Diana Domańska, Johannes R. Hov, Espen S. Bækkevold, F.L. Jahnsen
The paper identifies ultra long-lived plasma cells in the human small intestine that produce IgA antibodies reactive to a diverse microbiota, suggesting long-term immune memory shaping the microbiome.
Beneficial Microbes · May 11, 2026Peer-reviewedImmunology