Brain regional identity and cell type specificity landscape of human cortical organoid models
Manuela Magni, Beatrice Bossi, Paola Conforti, Maura Galimberti, Fabio Dezi, Tiziana Lischetti, Xiufang He, Roger A. Barker, Chiara Zuccato, Ira Espuny-Camacho, Elena F. Cattaneo
This study compares three cortical organoid protocols to assess brain regional identity, cell type specificity, and neuronal maturation, finding that directed differentiation methods yield higher regional identity while default methods produce broader cell type diversity.
International Journal of Molecular Sciences · Oct 29, 2022Peer-reviewedNeuroscience