Maura Galimberti

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.

This study shows that WDR62 mutations disrupt Golgi-to-spindle pole shuttling in neural progenitors, leading to neurodevelopmental abnormalities in microcephaly.

This study compares three cortical organoid protocols to assess brain regional identity, cell type specificity, and neuronal maturation, finding that directed differentiation methods yield higher regional identity while default methods produce broader cell type diversity.