Ira Espuny-Camacho

Organoid-to-organoid transplantation and pro-neurogenic treatment promote graft integration and neuronal repair in a human ischemic model

This study shows that combining organoid transplantation with pro-neurogenic treatment improves graft integration and neuronal repair in a human ischemic model.

Untangling mechanisms for cerebellar neural specification using human pluripotent stem cell-derived organoids

This study uses human pluripotent stem cell-derived cerebellar organoids to investigate human cerebellar development and disease-related gene expression.

Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids

This study shows SARS-CoV2 infects brain cells in cortical organoids, inducing reactive astrocyte states and inflammation.

Brain regional identity and cell type specificity landscape of human cortical organoid models

This study compares three cortical organoid protocols to assess brain regional identity, cell type specificity, and neuronal maturation, finding that directed differentiation methods yield higher regional identity while default methods produce broader cell type diversity.