Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.
Gina M. Aloisio, Divya Nagaraj, Ashley M. Murray, Emily M. Schultz, Trevor McBride, Letisha Aideyan, Erin G. Nicholson, David Henke, Laura Ferlic-Stark, Anubama Rajan, Amal Kambal, Hannah L. Johnson, Elina Mosa, Fabio Stossi, Sarah E. Blutt, , Vasanthi Avadhanula
This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.
bioRxiv · Feb 1, 2024 · PreprintMicrobiology