Vasanthi Avadhanula

This study shows that the order of RSV and RV infection in infants determines disease outcome through type III interferon-mediated viral interference.

This study shows RSV can infect respiratory epithelium via the basolateral route, targeting basal cells, with RSV/B/BA showing higher basolateral infectivity than RSV/A/ON.

This study shows that Streptococcus pneumoniae precolonization reduces RSV levels and modulates epithelial transcriptional responses to RSV infection more than other nasal bacteria.

This study analyzes RSV evolutionary dynamics across pre-pandemic, pandemic, and post-pandemic periods in Houston, finding reduced diversity during the pandemic and increased non-synonymous mutations in RSV/B.

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

This paper presents a probe-based capture enrichment method to obtain full-length genomes of RSV and HuNoV from clinical samples, achieving high completeness and improving variant tracking.

The paper analyzes intra-host RSV genetic variation using short-read sequencing, finding low variation but differences between genomic and transcriptomic data.

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

This study shows RSV gene expression is genotype-dependent and non-gradient, with the G gene consistently more expressed than upstream genes, suggesting a novel transcriptional regulation mechanism involving GS signal N-phase alignment.