Connexin-43 dependent ATP release mediates macrophage activation during peritonitis
Michel Dosch, Joël Zindel, Fadi Jebbawi, Nicolas Melin, Daniel Sanchez-Taltavull, Deborah Stroka, Daniel Candinas, Guido Beldi
This study shows that Connexin-43-mediated ATP release from macrophages via TLR-2 and -4 agonists promotes sepsis severity, and inhibiting this pathway improves survival in peritonitis.
bioRxiv · Sep 23, 2018 · PreprintImmunology