Deborah Stroka

Low-salt diet induces claudin-3 expression and drives adaptive changes in collecting duct of claudin-3-deficient mice

This study shows that a low-salt diet increases claudin-3 expression in mice, which reduces paracellular sodium permeability, and claudin-3-deficient mice adapt by upregulating other claudins and ENaC to maintain sodium balance.

Stress-induced vtRNA1-1 modulates redox homeostasis and ferroptosis susceptibility in hepatocellular carcinoma cells

This study identifies vtRNA1-1 as a short ncRNA that modulates ferroptosis susceptibility in HCC cells by regulating redox homeostasis through a reciprocal loop with NF-κB.

Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis

This study investigates how bacteria release ATP during sepsis and shows that bacterial ATP suppresses local immune responses and exacerbates systemic inflammation through outer membrane vesicles.

Tumour mutations in long noncoding RNAs enhance cell fitness

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

Single cell chronoatlas of regenerating mouse livers reveals early Kupffer cell proliferation

This study creates a single-cell time atlas of mouse liver regeneration after partial hepatectomy, revealing Kupffer cells as the first proliferating cell type.

Bayesian Correlation is a robust similarity measure for single cell RNA-seq data

The paper introduces Bayesian correlation as a robust similarity measure for scRNA-seq data, showing it outperforms Pearson correlation in reproducibility and biological relevance.

Connexin-43 dependent ATP release mediates macrophage activation during peritonitis

This study shows that Connexin-43-mediated ATP release from macrophages via TLR-2 and -4 agonists promotes sepsis severity, and inhibiting this pathway improves survival in peritonitis.