Engineering low pH-tolerant Komagataella phaffii for industrial-ready itaconic acid production via methanol biorefinery
Fangqing Wei, Xiao Han, Fei Tao, Ping Xu
This study engineers Komagataella phaffii to produce high-titer itaconic acid from methanol, achieving 103.8 g/L at pH 5.5 and 50.4 g/L at pH 3.5.
bioRxiv · Jan 29, 2025 · PreprintSynthetic Biology