Farida El Gaamouch

Phage Display-Derived Cyclic Peptides Target TREM2 and Modulate Microglial Responses under Amyloid Stress

This study identifies cyclic peptides that bind TREM2 and modulate microglial responses under amyloid stress, suggesting their potential as neuroimmune therapeutics.

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models

This paper identifies S9, a small molecule TREM2 agonist that reprograms microglia and protects synapses in Alzheimer's models, showing therapeutic potential.

High-Throughput Fragment Screening Identifies a New Small Molecule Scaffold that Modulates TREM2 Signaling

This study identifies a new small molecule scaffold that modulates TREM2 signaling through fragment-based drug discovery and SAR analysis.

AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity

Deep Docking virtual screening of over five million compounds and structure-activity optimization yielded T2M-010, a submicromolar small-molecule TREM2 agonist that induces SYK phosphorylation and microglial phagocytosis.

Structure-Based Virtual Screening Identifies TREM2-Targeted Small Molecules that Enhance Microglial Phagocytosis

This paper identifies a small molecule TREM2 modulator, EN020, that enhances microglial phagocytosis better than a known agonist.

As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition

As48 is a small molecule that activates TREM2 and inhibits its shedding, offering a dual mechanism to enhance microglial function in Alzheimer's disease.

TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization

This paper identifies first-in-class small molecule agonists of TREM2 through DEL screening, validates their binding and function, and suggests a novel activation mechanism.

TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach

This paper develops a high-throughput screening platform to identify small molecule TREM2 binders using TRIC technology, finding four validated hits with moderate binding affinities.

Discovery of an Achiral Small Molecule TREM2 Agonist with Im-proved Pharmacokinetic Profile and Validated Target Engagement

This paper describes the discovery of C1, an achiral TREM2 agonist with improved pharmacokinetics and validated target engagement compared to VG-3927.