Author
Weill Cornell MedicineORCID 0000-0001-6404-676XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Natalie S. Fuchs, Shaoren Yuan, Katarzyna Kuncewicz…·Moustafa Tarek Gabr
This study identifies cyclic peptides that bind TREM2 and modulate microglial responses under amyloid stress, suggesting their potential as neuroimmune therapeutics.
Natalie S. Fuchs, Farida El Gaamouch, Hossam Nada…·Moustafa Tarek Gabr
This study identifies a new small molecule scaffold that modulates TREM2 signaling through fragment-based drug discovery and SAR analysis.
Hossam Nada, Laura Calvo‐Barreiro, Natalie S. Fuchs…·Moustafa Tarek Gabr
HTS-Oracle uses AI to prioritize small molecule hits for challenging immune targets, reducing screening needs and increasing hit rates significantly.
Natalie S. Fuchs, Katarzyna Kuncewicz, Farida El Gaamouch, Moustafa Tarek Gabr
This paper develops a high-throughput screening platform to identify small molecule TREM2 binders using TRIC technology, finding four validated hits with moderate binding affinities.
Natalie S. Fuchs, Laura Calvo‐Barreiro, Valerij Talagayev…·Moustafa Tarek Gabr
The paper identifies two small molecule ligands for LAG-3 through virtual screening and experimental validation, with one showing cellular target engagement.