Sung‐Woo Cho

This paper identifies two small molecule CD28 inhibitors using AS-MS and validates their ability to block CD28-B7 interactions and suppress T cell activation in co-culture models.

This paper develops a heart-on-a-chip platform using human iPSC-derived cardiomyocytes and a multi-electrode array to evaluate drug-induced cardiotoxicity with high reproducibility and multi-angle analysis.

This paper identifies a novel druggable site on CD28 and discovers 22VS, a small molecule inhibitor that suppresses T cell activation in co-culture models, with favorable pharmacokinetic properties.

This paper describes the discovery of C1, an achiral TREM2 agonist with improved pharmacokinetics and validated target engagement compared to VG-3927.

This study identifies NF1/RASA1/TP53 co-mutations and MEK signaling as key drivers of sinonasal tumorigenesis through in vivo CRISPR screening and drug response testing.