Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow
Belem Yoval‐Sánchez, Ivan Guerrero, Qiuying Chen, Sergey A. Sosunov, Fariha Ansari, Max Siragusa, Csaba Konràd, Zoya V. Niatsetskaya, Анна Степанова, Anatoly A. Starkov, Sergei Khruschev, Jordi Magrané, Arina A. Nikitina, Oxana Bereshchenko, Ping Zhou, , Alexander S. Galkin
This study shows that expressing alternative oxidase (AOX) reduces reverse electron transfer and oxidative stress in ischemia-reperfusion brain injury, preserving complex I function and providing neuroprotection.
bioRxiv · May 19, 2025 · PreprintBiochemistry