Анна Степанова

This study shows that calcium dysregulation in Friedreich's ataxia fibroblasts enhances fibrotic responses to TGFβ by affecting NFAT-controlled genes and NCX1 function.

This study shows that expressing alternative oxidase (AOX) reduces reverse electron transfer and oxidative stress in ischemia-reperfusion brain injury, preserving complex I function and providing neuroprotection.

The paper shows adult human astrocytes lack key mitochondrial proteins needed for oxidative phosphorylation, leading to lactate production instead of OXPHOS.

This study shows that disrupted MAM function in ALS models leads to altered mitochondrial metabolism, specifically a shift from pyruvate to fatty acid utilization.

The paper shows that partial inhibition of mitochondrial complex I protects against neurodegeneration in Alzheimer's mice by improving energy homeostasis, synaptic function, and reducing inflammation.