Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
Robin E. Kruger, Tristan Frum, Anna Sophie Brumm, Stephanie L. Hickey, Kathy K. Niakan, Farina Aziz, Marcelio A. Shammami, Jada G. Roberts, Amy Ralston
The paper shows Smad4 is not required before implantation but is essential for epiblast morphogenesis after implantation in mice.
bioRxiv · Jan 23, 2024 · PreprintDevelopmental Biology