Tristan Frum

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

The paper establishes a human iPSC-derived co-culture model of pulmonary fibrosis that reveals bidirectional fibrogenic epithelial-mesenchymal crosstalk and identifies potential druggable pathways.

The paper constructs a cellular atlas of the early postnatal human lung and identifies two distinct AT2 cell states linked to inflammatory signaling and clinical interventions.

This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.

This paper develops a long-term in vitro model of human colonic epithelium that maintains barrier function for up to 30 days and responds to various challenges.

This study develops a Matrigel-free method using synthetic hydrogels to form alveolar organoids, showing they secrete their own extracellular matrix for growth.

The paper creates a spatially-resolved atlas of the developing human lung, identifying a WNT-driven niche that regulates basal cells.

The paper shows Smad4 is not required before implantation but is essential for epiblast morphogenesis after implantation in mice.

This study identifies opposing roles for TGFbeta and BMP signaling in generating AT2-like cells from lung progenitors in vitro.

This study develops iPSC-derived lung bud tip progenitor organoids that can be expanded and differentiated into airway or alveolar organoids, showing transcriptional similarity to in vivo progenitors.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

The paper shows that ex vivo culture conditions inhibit a key pathway for blastocyst lineage commitment in mice.

The paper shows that TEAD4/YAP1/WWTR1 repress Sox2 expression before the 16-cell stage in mouse embryos, preventing premature pluripotency.

The paper shows HIPPO signaling resolves cell fate conflicts by repositioning cells during pluripotency establishment in the mouse embryo.