Author

Anna Sophie Brumm

The Francis Crick InstituteORCID 0000-0001-8371-847XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Kathy K. NiakaniD· 2 shared Afshan McCarthyiD· 1 shared Alberto S. CeccarelliiD· 1 shared Ali Akbar Fouladi-NashtaiD· 1 shared Amy RalstoniD· 1 shared Anahí Binagui-CasasiD· 1 shared Anna Granés· 1 shared Caroline Hassitt· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Kathy K. NiakanORCID

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3 papers

Recent·Most cited

Developmental BiologyPLoS BiologyPeer-reviewedAug 25, 2026

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

Anahí Binagui-Casas, Anna Granés, Alberto S. Ceccarelli…·Valerie A. Wilson

The paper identifies two thresholds of Brachyury expression in NMPs that determine lineage potential and axis-forming ability in vitro.

3 citations

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJan 23, 2024

Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse

Robin E. Kruger, Tristan Frum, Anna Sophie Brumm…·Amy Ralston

The paper shows Smad4 is not required before implantation but is essential for epiblast morphogenesis after implantation in mice.

DOI 10.1101/2024.01.23.576717

mouseexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJul 1, 2022

A conserved role of Hippo signaling in initiation of the first lineage specification event across mammals

Claudia Gerri, Afshan McCarthy, Gwen Mei Scott…·Kathy K. Niakan

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

3 citations

𝕏 PostBluesky