Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis
Veerasikku Gopal Deepagan, Xiuquan Ma, Farzaneh Bazregari, Jiyi Pang, Jan Schaefer, Joanne M. Hildebrand, Ruby K. Dempsey, Marcel Doerflinger, Christopher A. Baldwin, Florian Ingo Schmidt, James M. Murphy, Ranja Salvamoser, James Edward Vince
This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.
Biochemical Journal · Aug 1, 2025Peer-reviewedBioengineering