Author

Florian Ingo Schmidt

University of BonnORCID 0000-0002-9979-9769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Maria H. ChristenseniD· 2 shared Adeline AugereauiD· 1 shared Alexander N.R. WeberiD· 1 shared Arnaud CarrieriD· 1 shared Charlotte Andrieu‐SoleriD· 1 shared Christopher A. Baldwin· 1 shared Clara TaffoniiD· 1 shared Clare Elizabeth BryantiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Maria H. ChristensenORCID

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4 papers

Recent·Most cited

Human NLRC4 can act as a direct sensor for cytosolic flagellin

Gaopeng Li, Kenyatta Doumanas, Xiao Liu, Nadya Panagides, Liudmila Andreeva, Florian Ingo Schmidt, Clare Elizabeth Bryant, Alexander N.R. Weber

This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.

bioRxiv · Oct 8, 2026 · PreprintImmunology

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma, Soumyabrata Guha, Roger-Junior Eloiflin, Adeline Augereau, Pierre Le Hars, Moritz Schüssler, Yasmine Messaoud-Nacer, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A. Disyak, Clara Taffoni, Robin Charpentier, , Nadine Laguette

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

Nature Communications · Nov 7, 2025Peer-reviewedImmunology

Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis

Veerasikku Gopal Deepagan, Xiuquan Ma, Farzaneh Bazregari, Jiyi Pang, Jan Schaefer, Joanne M. Hildebrand, Ruby K. Dempsey, Marcel Doerflinger, Christopher A. Baldwin, Florian Ingo Schmidt, James M. Murphy, Ranja Salvamoser, James Edward Vince

This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.

Biochemical Journal · Aug 1, 2025Peer-reviewedBioengineering

A novel reporter to visualize and quantify endogenous inflammasomes and caspase-1 recruitment

Florian N. Gohr, Maria H. Christensen, Lea‐Marie Jenster, Yonas M. Tesfamariam, Dorothee J. Lapp, Jason M. Mackenzie, Florian Ingo Schmidt

This paper develops a fluorescent reporter to visualize and quantify endogenous inflammasome assembly and caspase-1 recruitment in real-time.

bioRxiv · Mar 30, 2025 · PreprintImmunology