James Edward Vince

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

Inhibition of Gasdermin D by Disulfiram Attenuates Cardiac Inflammation and Fibrosis following Ischaemia Reperfusion Injury

This paper shows that Disulfiram reduces cardiac inflammation and fibrosis after heart attack by inhibiting the GSDMD pathway.

Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis

This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.