Marcel Doerflinger

Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of Plasmodium falciparum sporozoite-host interactions

The paper develops a CRISPR-based system using Cas9-expressing hepatocytes to study Plasmodium falciparum host interactions, validating its utility for screening host genes involved in infection.

IL-1β and TNF drive endothelial dysfunction and coagulopathy in acute COVID-19.

This study identifies TNF and IL-1β as key drivers of endothelial dysfunction and coagulopathy in acute SARS-CoV-2 infection using in vitro and in vivo models.

Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis

This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.