Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasation
Angela K. Spartz, Susan Schmidt, Fazila Mohamed, Benjamin Troness, Carol Ann Lange, Dorraya El‐Ashry
This study shows that circulating cancer-associated fibroblasts (cCAFs) enhance breast cancer cell extravasation by promoting urokinase plasminogen activator (uPA) expression, facilitating metastasis.
bioRxiv · Jun 11, 2025 · PreprintCancer Biology