Structure-guided generative design of peptides targeting the FtsQBL divisome complex inhibit Escherichia coli cell division.
Pauline Remont, Xiaosong Liu, Federico Croci, Ariel Méchaly, Gouzel Karimova, Minh-Ha Nguyen, Iñaki Guijarrro, Marilyne Davi, Cécile Guillon, Constantin Bogdan Ciambur, Fabrice Agou, Alix Boucharlat, Ahmed Haouz, Jeanne Chiaravalli, Daniel Ladant, Olivier Spérandio
This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.
bioRxiv · Mar 1, 2026 · PreprintMicrobiology