Ahmed Haouz

This study evolves a DNA polymerase into a reverse transcriptase for modified RNA using directed evolution, revealing sequence-to-function relationships through integrated analysis.

The paper characterizes the regulatory mechanism of class II bacterial IMPDH from Burkholderia thailandensis, showing MgGTP's dual role in enzyme activity and oligomerization.

This study defines the structural basis of MfpD function using phylogenetic, structural, and biophysical approaches, revealing its role in promoting GTP hydrolysis by MfpB through a noncanonical mechanism.

This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.

This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.

The paper identifies accessory PDFs in bacterial genomes that confer resistance to PDF inhibitors and are mobile, posing a challenge for antibiotic development.

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

This paper identifies HdpA's interaction with LhiA, a chaperone that regulates its activity, and shows how this complex controls peptidoglycan remodeling and shape transition in H. pylori.

The paper investigates how DNA polymerases in Paramecium tetraurelia ensure high fidelity during programmed DNA rearrangements by analyzing structural changes in polymerase lambda mutants.

This study investigates the regulatory mechanism of RipA, a cell wall hydrolase in Mtb, through structural and functional analysis of the SteAB system.

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

This study reveals how archaeal RPA's winged-helix domain interacts with DNA primase and polymerase, enhancing PriSL activity and providing insights into replication regulation.

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.