Ariel Méchaly

This paper validates Corynebacterium glutamicum as a non-pathogenic surrogate for Mycobacterium tuberculosis to study DNA gyrase and discover new inhibitors.

The paper identifies a seven-protein complex that stabilizes and facilitates the secretion of the T7SSb effector TelE in SGG.

This study presents the cryo-EM structure of inactive ADGRV1 and shows it has weak constitutive activation and an alternative activation mechanism distinct from other aGPCRs.

This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.

This paper identifies small molecules that inhibit the SARS-CoV-2 E protein interaction with ZO-1 PDZ2 using X-ray crystallography, HTRF screening, and docking simulations, with one compound showing antiviral activity.

The paper identifies accessory PDFs in bacterial genomes that confer resistance to PDF inhibitors and are mobile, posing a challenge for antibiotic development.

This paper identifies HdpA's interaction with LhiA, a chaperone that regulates its activity, and shows how this complex controls peptidoglycan remodeling and shape transition in H. pylori.