Structural basis for ATP regulation of human 5-lipoxygenase
Tarvi Teder, Federico Pozzani, Tim Paul Schulte, A. Hosseini, Olof Rådmark, Laura Orellana, Jesper Z. Haeggström
This study presents a cryo-EM structure of human 5-lipoxygenase bound to ATP, revealing how ATP regulates enzyme activity through specific amino acid interactions and conformational changes.
bioRxiv · Nov 26, 2025 · PreprintBiochemistry