How do gepotidacin and zolifodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A Single Moving Metal Mechanism.
Robert A. Nicholls, Harry Morgan, Anna J. Warren, Simon E. Ward, Fei Long, Garib N. Murshudov, Dmitry A. Sutormin, B.D. Bax
This paper proposes a single moving metal-ion mechanism for DNA-cleavage by type IIA topoisomerases using crystal structures of Staphylococcus aureus DNA gyrase complexes with gepotidacin and zolifodacin.
International Journal of Molecular Sciences · Dec 24, 2024Peer-reviewedBiophysics