BiophysicsInternational Journal of Molecular SciencesPeer-reviewed
How do gepotidacin and zolifodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A Single Moving Metal Mechanism.
Robert A. Nicholls, Harry Morgan, Anna J. Warren…·B.D. Bax
This paper proposes a single moving metal-ion mechanism for DNA-cleavage by type IIA topoisomerases using crystal structures of Staphylococcus aureus DNA gyrase complexes with gepotidacin and zolifodacin.