Author

Robert A. Nicholls

MRC Laboratory of Molecular BiologyORCID 0000-0002-8577-8617Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Assay:protein structure· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Garib N. MurshudoviD· 3 shared Anna J. WarreniD· 2 shared B.D. BaxiD· 2 shared Harry MorganiD· 2 shared Simon E. WardiD· 2 shared Dmitry A. SutorminiD· 1 shared Fei Long· 1 shared Fei LongiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

Garib N. MurshudovORCID

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3 papers

Recent·Most cited

How do gepotidacin and zolifodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A Single Moving Metal Mechanism.

Robert A. Nicholls, Harry Morgan, Anna J. Warren, Simon E. Ward, Fei Long, Garib N. Murshudov, Dmitry A. Sutormin, B.D. Bax

This paper proposes a single moving metal-ion mechanism for DNA-cleavage by type IIA topoisomerases using crystal structures of Staphylococcus aureus DNA gyrase complexes with gepotidacin and zolifodacin.

International Journal of Molecular Sciences · Dec 24, 2024Peer-reviewedBiophysics

How do gepotidacin and zoliflodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 1. Experimental definition of metal binding sites

Harry Morgan, Robert A. Nicholls, Anna J. Warren, Simon E. Ward, Gwyndaf Evans, Fei Long, Garib N. Murshudov, Ramona Duman, B.D. Bax

International Journal of Molecular Sciences · Oct 30, 2024Peer-reviewedBiophysics

Neutron crystallographic refinement with REFMAC5 of the CCP4 suite

Lucrezia Catapano, Fei Long, Keitaro Yamashita, Robert A. Nicholls, Roberto A. Steiner, Garib N. Murshudov

This paper extends the REFMAC5 program in the CCP4 suite to refine macromolecular models using neutron crystallographic data, improving the accuracy of hydrogen atom localization.

bioRxiv · Aug 13, 2023 · PreprintBioinformatics