Author

Simon E. Ward

Cardiff UniversityORCID 0000-0002-8745-8377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Anna J. WarreniD· 2 shared B.D. BaxiD· 2 shared Garib N. MurshudoviD· 2 shared Harry MorganiD· 2 shared Robert A. NichollsiD· 2 shared Abdulrahman AlatawiiD· 1 shared Alex HerbertiD· 1 shared Antony W. OliveriD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersBiophysics

Anna J. WarrenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan B. Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon Alexander Harper, , Helfrid Hochegger

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Nature Communications · Aug 27, 2025Peer-reviewedCell Biology

How do gepotidacin and zolifodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A Single Moving Metal Mechanism.

Robert A. Nicholls, Harry Morgan, Anna J. Warren, Simon E. Ward, Fei Long, Garib N. Murshudov, Dmitry A. Sutormin, B.D. Bax

This paper proposes a single moving metal-ion mechanism for DNA-cleavage by type IIA topoisomerases using crystal structures of Staphylococcus aureus DNA gyrase complexes with gepotidacin and zolifodacin.

International Journal of Molecular Sciences · Dec 24, 2024Peer-reviewedBiophysics

Inhibition of acid ceramidase as a therapeutic strategy for Niemann-Pick C disease

Isabelle Haynes, Simon E. Ward, Dyfyr Heulyn Jones, Emyr Lloyd‐Evans, Helen Waller‐Evans

This study identifies acid ceramidase as a potential therapeutic target for Niemann-Pick C disease by reducing lipid accumulation in a cellular model.

bioRxiv · Nov 13, 2024 · PreprintCell Biology

How do gepotidacin and zoliflodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 1. Experimental definition of metal binding sites

Harry Morgan, Robert A. Nicholls, Anna J. Warren, Simon E. Ward, Gwyndaf Evans, Fei Long, Garib N. Murshudov, Ramona Duman, B.D. Bax

International Journal of Molecular Sciences · Oct 30, 2024Peer-reviewedBiophysics