Disease modification upon brief exposure to tofacitinib during chronic epilepsy.
Olivia R. Hoffman, Jennifer L. Koehler, Jose Ezekiel Clemente Espina, Anna M. Patterson, Emily S. Gohar, Emanuel M. Coleman, Barry A. Schoenike, Claudia Espinosa‐García, Felipe Paredes, Nicholas H. Varvel, Raymond J Dingledine, Jamie L. Maguire, Avtar Roopra
The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.
bioRxiv · Aug 7, 2023 · PreprintNeuroscience