Claudia Espinosa‐García

Network analysis of mouse brain proteomes resolves molecular and cellular endophenotypes of aging and Aβ pathology

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

Chronic Sleep Disruption Activates the Transcriptional Unfolded Protein Response and Induces Compartment-Specific Proteomic Changes in Mice

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

Deeper neuronal and glial proteomic insights using an optimized pipeline for proximity labeling proteomics

The paper optimizes a proximity labeling proteomics pipeline to enhance proteome coverage in neuronal and glial cells, revealing deeper insights into their biological functions and disease relevance.

Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

Disease modification upon brief exposure to tofacitinib during chronic epilepsy.

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology