Author

Raymond J Dingledine

Emory UniversityORCID 0000-0001-7128-4520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Nicholas H. VarveliD· 3 shared Avtar RoopraiD· 2 shared Barry A. Schoenike· 2 shared Anna M. PattersoniD· 1 shared Ariel Biegel· 1 shared Caleb Sindic· 1 shared Claudia Espinosa‐GarcíaiD· 1 shared Di CheniD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Nicholas H. VarvelORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 19, 2025

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures

Soheila Pourkhodadad, Wenyi Wang, Raymond J Dingledine, Nicholas H. Varvel

This study shows that brief CCR2 antagonism after seizures prevents cognitive deficits and neurodegeneration by blocking monocyte brain infiltration.

1 citation

mouseexperimental assay

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NeurosciencebioRxivPreprintAug 7, 2023

Disease modification upon brief exposure to tofacitinib during chronic epilepsy.

Olivia R. Hoffman, Jennifer L. Koehler, Jose Ezekiel Clemente Espina…·Avtar Roopra

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

2 citations

mousebulk RNA-seq

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NeurosciencePLoS ONEPeer-reviewedDec 31, 2019

A Systems Approach Identifies Enhancer of Zeste Homolog 2 (EZH2) as a Protective Factor in Epilepsy

Nadia Khan, Barry A. Schoenike, Trina Basu…·Avtar Roopra

This paper identifies EZH2 as a protective factor in epilepsy using a systems approach to analyze transcriptomic data from rodent and human samples.

22 citations

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NeurosciencebioRxivPreprintAug 19, 2018

Opposing effects of prostaglandin receptor EP2 signaling in mouse immune cells and neurons after status epilepticus

Nicholas H. Varvel, Di Chen, Ariel Biegel, Raymond J Dingledine

The paper identifies opposing effects of EP2 receptor signaling in immune cells and neurons after status epilepticus, showing immune cell EP2 is harmful while neuronal EP2 is protective.

1 citation

mouseexperimental assay

𝕏 PostBluesky