Author

Nicholas H. Varvel

Emory UniversityORCID 0000-0002-0351-1098Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Raymond J DingledineiD· 3 shared Anna M. PattersoniD· 1 shared Ariel Biegel· 1 shared Avtar RoopraiD· 1 shared Barry A. Schoenike· 1 shared Claudia Espinosa‐GarcíaiD· 1 shared Di CheniD· 1 shared Emanuel M. ColemaniD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Raymond J DingledineORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 19, 2025

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures

Soheila Pourkhodadad, Wenyi Wang, Raymond J Dingledine, Nicholas H. Varvel

This study shows that brief CCR2 antagonism after seizures prevents cognitive deficits and neurodegeneration by blocking monocyte brain infiltration.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 7, 2023

Disease modification upon brief exposure to tofacitinib during chronic epilepsy.

Olivia R. Hoffman, Jennifer L. Koehler, Jose Ezekiel Clemente Espina…·Avtar Roopra

The paper shows that brief tofacitinib treatment suppresses seizures and reverses cognitive deficits in chronic epilepsy by targeting a resurgent JAK/STAT pathway activation.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 19, 2018

Opposing effects of prostaglandin receptor EP2 signaling in mouse immune cells and neurons after status epilepticus

Nicholas H. Varvel, Di Chen, Ariel Biegel, Raymond J Dingledine

The paper identifies opposing effects of EP2 receptor signaling in immune cells and neurons after status epilepticus, showing immune cell EP2 is harmful while neuronal EP2 is protective.

1 citation

mouseexperimental assay

𝕏 PostBluesky