DICER1 syndrome mutations lead to a gain of 3p-miRNA function, HERVH activity and increased metastatic potential
Katrina Gordon, Nicolás Bellora, Jeroen Witteveldt, Joanna K. Wojtus, Felix Mueller, Katharina J. Kases, Pilar G. Marchante, Guillermo Peris, Shelagh Boyle, Sara R. Heras, Atlanta G. Cook, Cei Abreu‐Goodger, Sara Macías
This study shows that DICER1 mutations lead to increased 3p-miRNA activity, HERVH activation, and metastatic potential without causing genomic instability.
bioRxiv · Dec 16, 2025 · PreprintMolecular Biology