Jeroen Witteveldt

The paper identifies endogenous double-stranded RNAs in mammalian embryonic stem cells by developing a method combining antibody-based purification and RNase I treatment, revealing transposable elements as their main source.

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

This study shows that DICER1 mutations lead to increased 3p-miRNA activity, HERVH activation, and metastatic potential without causing genomic instability.

The paper shows that pluripotent mouse embryonic stem cells silence MDA5 to avoid endogenous dsRNA recognition, preventing IFN activation and ensuring normal development.