Sara R. Heras

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

This study shows that DICER1 mutations lead to increased 3p-miRNA activity, HERVH activation, and metastatic potential without causing genomic instability.

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

The paper shows that pluripotent mouse embryonic stem cells silence MDA5 to avoid endogenous dsRNA recognition, preventing IFN activation and ensuring normal development.

This study shows BMAL1 represses transposable elements in pluripotent cells independently of CLOCK, leading to genome-wide changes and totipotency features when BMAL1 is deleted.

This study shows that let-7 microRNA reduces LINE-1 retrotransposition by inhibiting ORF2p translation in human lung cancer.

This study shows LINE-1 retrotransposition occurs in human pre-implantation embryos and extraembryonic tissues, impacting gene expression and potentially contributing to genomic variation.