Guillermo Peris

The paper identifies endogenous double-stranded RNAs in mammalian embryonic stem cells by developing a method combining antibody-based purification and RNase I treatment, revealing transposable elements as their main source.

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

This study shows that DICER1 mutations lead to increased 3p-miRNA activity, HERVH activation, and metastatic potential without causing genomic instability.

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

This study shows BMAL1 represses transposable elements in pluripotent cells independently of CLOCK, leading to genome-wide changes and totipotency features when BMAL1 is deleted.

This study shows that let-7 microRNA reduces LINE-1 retrotransposition by inhibiting ORF2p translation in human lung cancer.