Tiarins, a diverse family of natural Trojan-horse aminoacyl-tRNA synthetase inhibitors discovered by genome mining
Dmitrii Y. Travin, Aleksei Livensky, Dmitry Bikmetov, Constantine D. Pavlov, Marina Serebryakova, Konstantin Gilep, Fengjie Wu, Delphine Naquin, Tatiana Timchenko, Guy M. Lippens, Séverine Zirah, Peter Mergaert, Svetlana A. Dubiley
The paper identifies TFX as an antibiotic that inhibits arginyl-tRNA synthetase by acting as a Trojan-horse molecule, revealing it belongs to a broader family of natural inhibitors targeting various tRNA synthetases.
bioRxiv · Dec 2, 2025 · PreprintMolecular Biology