Dmitrii Y. Travin

The paper identifies TFX as an antibiotic that inhibits arginyl-tRNA synthetase by acting as a Trojan-horse molecule, revealing it belongs to a broader family of natural inhibitors targeting various tRNA synthetases.

This study identifies bottromycin's mechanism of action as selectively trapping EF-Tu/glycyl-tRNA complex on the ribosome, inhibiting translation at glycine codons.

The paper shows that TopoI interacts with RNA polymerase in E. coli to prevent R-loop formation by relaxing negative supercoiling during transcription.

The paper identifies two distinct transporters, BacA and YejABEF, that mediate the uptake of the peptide antibiotic phazolicin in Sinorhizobium meliloti, reducing resistance acquisition.

The paper discovers a new LAP antibiotic, phazolicin, which inhibits bacterial ribosomes in a species-specific manner by blocking the exit tunnel.