Konstantin Gilep

The paper maps virus-host protein contact sites during influenza A virus infection, revealing new interactions and paraspeckle disassembly as a novel infection mechanism.

The paper identifies TFX as an antibiotic that inhibits arginyl-tRNA synthetase by acting as a Trojan-horse molecule, revealing it belongs to a broader family of natural inhibitors targeting various tRNA synthetases.

AlphaPulldown2 provides a pipeline for high-throughput protein structural modeling with automated workflows and improved data management.

This study improves AlphaFold 3 by integrating crosslink data as covalently-bound ligands, enhancing model accuracy for complexes with limited evolutionary data.