Guy M. Lippens

Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

This paper identifies BVL3572S as a compound that inhibits HisC and AlaA in Mtb, causing metabolic stress and showing synergy with existing drugs.

Selective labeling supports 5-thiooxazole post-translational modification in bufferins

The paper identifies 5-thiooxazoles as the cysteine post-translational modifications in bufferins using isotopic labeling and confirms consistency with related MNIO families.

Tiarins, a diverse family of natural Trojan-horse aminoacyl-tRNA synthetase inhibitors discovered by genome mining

The paper identifies TFX as an antibiotic that inhibits arginyl-tRNA synthetase by acting as a Trojan-horse molecule, revealing it belongs to a broader family of natural inhibitors targeting various tRNA synthetases.

Towards site-specific information on PET degrading enzymesusing NMR near operational temperature

This paper improves NMR spectroscopy for studying PET-degrading enzymes by recording spectra at higher temperatures, enhancing signal-to-noise ratios and enabling faster backbone assignment.

MultiNMRFit: A software to fit 1D and pseudo-2D NMR spectra

MultiNMRFit is a software tool for analyzing NMR spectra to extract signal parameters, offering flexibility and robustness in metabolomics and isotope labeling studies.

Estimating flux dynamics from metabolite concentration time courses with dynafluxr

The paper introduces dynafluxr, a method to estimate metabolic flux dynamics from metabolite concentration time courses using constrained B-splines, showing it works well on both simulated and experimental data.

Multinuclear non-heme iron dependent oxidative enzymes: Landscape of their substrates, partner proteins and biosynthetic gene clusters

The paper identifies and characterizes the diversity of substrates and partner proteins for multinuclear non-heme iron-dependent oxidative (MNIO) enzymes, revealing new insights into their role in bacterial copper homeostasis and potential broader stress responses.

A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to copper stress

This paper identifies bufferins, a widespread family of ribosomal peptide metallophores that help bacteria adapt to copper stress by sequestering excess copper ions.

IsoSolve: an integrative framework to improve isotopic coverage and consolidate isotopic measurements by MS and/or NMR

IsoSolve integrates isotopic measurements from MS and NMR to improve isotopic coverage and consolidate data for metabolic network analysis.

Interact: Automated analysis of protein-ligand interactions by 1D and 2D NMR

Interact automates analysis of 1D and 2D NMR titration experiments to quantify protein-ligand interactions through peak picking, annotation, and fitting procedures.