TDP-43 regulates chromatin looping and gene transcription through binding and stabilizing DNA G-quadruplex structures
Fengy Yang, Suyang Zhang, Xiaofan Guo, Yulong Qiao, Y S Zhang, Sun H, Xiaona Chen, H T Wang
This study shows TDP-43 binds and stabilizes DNA G-quadruplexes, enhancing chromatin looping and gene expression in K562 and HepG2 cells.
bioRxiv · May 15, 2026 · PreprintBioinformatics