Suyang Zhang

TDP-43 regulates chromatin looping and gene transcription through binding and stabilizing DNA G-quadruplex structures

This study shows TDP-43 binds and stabilizes DNA G-quadruplexes, enhancing chromatin looping and gene expression in K562 and HepG2 cells.

DNA G-quadruplex Profiling Reveals Functional and Mechanistic Role of G-quadruplexes in Skeletal Muscle Stem Cells

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation

This study identifies the structural basis of RECQL5-induced RNA polymerase II transcription braking and reveals its coordination with the TCR complex for reactivation.

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

The paper reports the cryo-EM structure of a transcribing Pol II-U1 snRNP complex with DSIF and SPT6, showing how phosphorylated Pol II and SPT6 interact with U1 snRNP to facilitate spliceosome assembly and transcription processivity.

seRNA PAM-1 regulates skeletal muscle satellite cell activation and aging through trans regulation of Timp2 expression synergistically with Ddx5

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.

Structure of a transcribing RNA polymerase II-U1 snRNP complex

The paper reports the cryo-EM structure of a mammalian transcribing RNA polymerase II-U1 snRNP complex and describes its role in co-transcriptional splicing.