Xiaona Chen

This study shows TDP-43 binds and stabilizes DNA G-quadruplexes, enhancing chromatin looping and gene expression in K562 and HepG2 cells.

caRBP-Pred predicts chromatin-associated RNA-binding proteins using short peptide sequences, achieving an AUC of 0.81 and identifying 52 potential caRBPs in mice.

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

This study identifies RNA binding proteins (RBPs) as key regulators of TAD organization through their enrichment at TAD boundaries and synergistic interaction with nascent transcripts.

This study shows DHX36 binding remodels RNA structure, particularly in 3UTRs, leading to decreased mRNA abundance via m6A and YTHDF1 interactions.

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.