Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin
Michelle Chan, Han Yuan, Ilya Soifer, Tobias M. Maile, Rebecca Y. Wang, Andrea Ireland, Jonathon J. O’Brien, Jérôme Goudeau, Leanne Chan, Twaritha Vijay, Adam Freund, Cynthia J. Kenyon, Bryson D. Bennett, Fiona McAllister, David R. Kelley, , David G. Hendrickson
The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.
eLife · Feb 4, 2022Peer-reviewedGenomics